The U.S. Food and Drug Administration (FDA) recently published an article titled PRISM Identifies Vaccine Safety Issues. PRISM, an acronym for Post-licensure Rapid Immunization Safety Monitoring System, is a cooperative effort between the FDA’s Center for Biologics Evaluation and Research and its partners in the healthcare and medical insurance communities. This powerful, computer-based system can investigate adverse events to determine if there are connections to specific vaccines by analyzing critical bits of information separated from vast streams of healthcare data.